Format

Send to

Choose Destination
Nutrients. 2017 Dec 23;10(1). pii: E10. doi: 10.3390/nu10010010.

Association between Malnutrition and 28-Day Mortality and Intensive Care Length-of-Stay in the Critically ill: A Prospective Cohort Study.

Author information

1
Discipline of Nutrition and Dietetics, School of Health Sciences, Flinders University, GPO Box 2100, Adelaide SA 5001 Australia. charles_lew@nuhs.edu.sg.
2
Dietetics and Nutrition Department, Ng Teng Fong General Hospital, Singapore City 609606, Singapore. charles_lew@nuhs.edu.sg.
3
Dietetics and Nutrition Department, Ng Teng Fong General Hospital, Singapore City 609606, Singapore. gabriel_wong@nuhs.edu.sg.
4
Dietetics and Nutrition Department, Ng Teng Fong General Hospital, Singapore City 609606, Singapore. kpcheungapril@gmail.com.
5
Department of Respiratory Medicine, Ng Teng Fong General Hospital, Singapore City 609606, Singapore. ai_ping_chua@nuhs.edu.sg.
6
Saw Swee Hock School of Public Health, National University of Singapore, Singapore City 119077, Singapore. mary_chong@nus.edu.sg.
7
Discipline of Nutrition and Dietetics, School of Health Sciences, Flinders University, GPO Box 2100, Adelaide SA 5001 Australia. michelle.miller@flinders.edu.au.

Abstract

There is limited evidence for the association between malnutrition and mortality as well as Intensive Care Unit length-of-stay (ICU-LOS) in critically ill patients. We aimed to examine the aforementioned associations by conducting a prospective cohort study in an ICU of a Singapore tertiary hospital. Between August 2015 and October 2016, all adult patients with ≥ 24 h of ICU-LOS were included. The 7-point Subjective Global Assessment (7-point SGA) was used to determine patients' nutritional status within 48 h of ICU admission. Multivariable regressions were conducted in two ways: (1) presence versus absence of malnutrition, and (2) dose-dependent association for each 1-point decrease in the 7-point SGA. There were 439 patients of which 28.0% were malnourished, and the 28-day mortality rate was 28.0%. Malnutrition was associated with an increased risk of 28-day mortality (adjusted Relative Risk 1.33 (95% Confidence Interval: 1.05-1.69)), and this risk increased with a greater degree of malnutrition (adjusted Relative Risk 1.08 (95% Confidence Interval: 1.00-1.16) for each 1-point decrease in the 7-point SGA). No significant association was found between malnutrition and ICU-LOS. The results of this study indicated a clear association between malnutrition and higher 28-day mortality in critically ill patients. The association between malnutrition and ICU-LOS could not be replicated and hence requires further evaluation.

KEYWORDS:

critical illness; length-of-stay; malnutrition; mortality; nutritional assessment

PMID:
29295506
PMCID:
PMC5793238
DOI:
10.3390/nu10010010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center