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Int J Mol Sci. 2017 Dec 23;19(1). pii: E39. doi: 10.3390/ijms19010039.

BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration.

Author information

1
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain. blancamh@ucm.es.
2
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain. annalisa.addante@gmail.com.
3
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain. munozas@ucm.es.

Abstract

Bone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β) family. Initially identified due to their ability to induce bone formation, they are now known to have multiple functions in a variety of tissues, being critical not only during development for tissue morphogenesis and organogenesis but also during adult tissue homeostasis. This review focus on the liver as a target tissue for BMPs actions, devoting most efforts to summarize our knowledge on their recently recognized and/or emerging roles on regulation of the liver regenerative response to various insults, either acute or chronic and their effects on development and progression of liver fibrosis in different pathological conditions. In an attempt to provide the basis for guiding research efforts in this field both the more solid and more controversial areas of research were highlighted.

KEYWORDS:

BMP; TGF-β; chronic liver disease; fibrosis; liver; regeneration

PMID:
29295498
PMCID:
PMC5795989
DOI:
10.3390/ijms19010039
[Indexed for MEDLINE]
Free PMC Article

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