Format

Send to

Choose Destination
Mol Biol Evol. 2017 Dec 19. doi: 10.1093/molbev/msx322. [Epub ahead of print]

Genetic architecture and selection of Chinese cattle revealed by whole genome resequencing.

Author information

1
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
2
BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China.
3
Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA.
4
USDA-ARS, Animal Genomics and Improvement Laboratory, Beltsville, Maryland 20705, USA.
5
Department of Animal Science, McGill University, Montreal, Canada.
6
Department of animal science, Texas A&M University, Texas 77843, USA.
7
Yangling Vocational & Technical College, Yangling 712100, China.
8
School of Biomedical Sciences, Charles Sturt University, New South Wales 2678, Australia.
9
BGI-Shenzhen, Shenzhen 518083, China.
10
James D. Watson Institute of Genome Sciences, Hangzhou 310058, China.

Abstract

The bovine genetic resources in China are diverse, but their value and potential are yet to be discovered. To determine the genetic diversity and population structure of Chinese cattle, we analysed the whole genomes of 46 cattle from six phenotypically and geographically representative Chinese cattle breeds, together with 18 Red Angus cattle (RAN) genomes, 11 Japanese black cattle (JBC) genomes and taurine and indicine genomes available from previous studies. Our results showed that Chinese cattle originated from hybridization between Bos taurus and Bos indicus. Moreover, we found that the level of genetic variation in Chinese cattle depends upon the degree of indicine content. We also discovered many potential selective sweep regions associated with domestication related to breed-specific characteristics, with selective sweep regions including genes associated with coat colour (ERCC2, MC1R, ZBTB17 and MAP2K1), dairy traits (NCAPG, MAPK7, FST, ITFG1, SETMAR, PAG1, CSN3 and RPL37A), and meat production/quality traits (such as BBS2, R3HDM1, IGFBP2, IGFBP5, MYH9, MYH4 and MC5R). These findings substantially expand the catalogue of genetic variants in cattle and reveal new insights into the evolutionary history and domestication traits of Chinese cattle.

KEYWORDS:

Chinese cattle; admixture; indicine components; selection; :whole genome sequencing

PMID:
29294071
DOI:
10.1093/molbev/msx322

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center