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A A Pract. 2018 Jun 15;10(12):313-315. doi: 10.1213/XAA.0000000000000695.

Scrambler Therapy for the Treatment of Chronic Central Pain: A Case Report.

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From the CALMAR Pain Relief, LLC, Bonita Springs, Florida.
Johns Hopkins School of Nursing, Baltimore, Maryland.
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Harry J. Duffey Family Patient and Family Services Program and the Sidney Kimmel Comprehensive Cancer Program, Johns Hopkins Medical Institutions, Baltimore, Maryland.


Central pain syndromes affect several million people worldwide. A 52-year-old woman had central pain manifest as burning pain from her left foot to the knee for 12 years after treatment for a medullary cavernoma diagnosed after a right-sided brainstem bleeding episode. All this time, her baseline pain was 5-6/10 with spikes to 9-10/10 during activity. She underwent 10 daily Scrambler (Calmare) Therapy treatments (GEOMC, Inc, Seoul, Korea) with reduction in her pain from 9-10/10 to 0-0.5/10, then 5 more sessions a month later. Her baseline pain stayed at 2/10 at 140 days with spikes only to 5/10, and no additional medications. Scrambler (Calmare) Therapy deserves further study in central pain.

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