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Neuroimage. 2018 May 1;171:199-208. doi: 10.1016/j.neuroimage.2017.12.080. Epub 2017 Dec 30.

Polar-angle representation of saccadic eye movements in human superior colliculus.

Author information

1
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Core for Advanced Magnet Resonance Imaging, Baylor College of Medicine, Houston, TX 77030, USA; Texas A&M Health Science Center College of Medicine, Bryan, TX 77807, USA.
2
Departments of Neuroscience and Psychology, The University of Texas at Austin, 78712, USA.
3
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Core for Advanced Magnet Resonance Imaging, Baylor College of Medicine, Houston, TX 77030, USA.
4
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Core for Advanced Magnet Resonance Imaging, Baylor College of Medicine, Houston, TX 77030, USA; Departments of Neuroscience and Psychology, The University of Texas at Austin, 78712, USA. Electronic address: ress@bcm.edu.

Abstract

The superior colliculus (SC) is a layered midbrain structure involved in directing both head and eye movements and coordinating visual attention. Although a retinotopic organization for the mediation of saccadic eye-movements has been shown in monkey SC, in human SC the topography of saccades has not been confirmed. Here, a novel experimental paradigm was performed by five participants (one female) while high-resolution (1.2-mm) functional magnetic resonance imaging was used to measure activity evoked by saccadic eye movements within human SC. Results provide three critical observations about the topography of the SC: (1) saccades along the superior-inferior visual axis are mapped across the medial-lateral anatomy of the SC; (2) the saccadic eye-movement representation is in register with the retinotopic organization of visual stimulation; and (3) activity evoked by saccades occurs deeper within SC than that evoked by visual stimulation. These approaches lay the foundation for studying the organization of human subcortical - and enhanced cortical mapping - of eye-movement mechanisms.

KEYWORDS:

Attention; Saccades; Subcortical vision; Superior colliculus; Topography; fMRI

PMID:
29292132
PMCID:
PMC6844626
DOI:
10.1016/j.neuroimage.2017.12.080
[Indexed for MEDLINE]
Free PMC Article

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