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Trends Biochem Sci. 2018 Feb;43(2):136-148. doi: 10.1016/j.tibs.2017.12.003. Epub 2017 Dec 29.

Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity.

Author information

1
Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University, New York, NY 10032, USA; Department of Genetics and Development, Columbia University, New York, NY 10032, USA.
2
Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University, New York, NY 10032, USA; Department of Genetics and Development, Columbia University, New York, NY 10032, USA. Electronic address: zz2401@cumc.columbia.edu.

Abstract

During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of histone chaperones as well as by histone-modifying enzymes. In recent years novel insights into nucleosome assembly of new H3-H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process. Moreover, in vitro reconstitution of chromatin replication has shed light on nucleosome assembly of parental H3-H4, a process that remains elusive. Finally, recent studies have revealed that the replication-coupled nucleosome assembly is important for the determination and maintenance of cell fate in multicellular organisms.

KEYWORDS:

DNA replication; cell fate maintenance; epigenetic inheritance; histone modifications; nucleosome assembly

PMID:
29292063
PMCID:
PMC5805396
DOI:
10.1016/j.tibs.2017.12.003
[Indexed for MEDLINE]
Free PMC Article

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