Format

Send to

Choose Destination
Breast Cancer Res. 2018 Jan 2;20(1):1. doi: 10.1186/s13058-017-0925-3.

SNPs related to vitamin D and breast cancer risk: a case-control study.

Author information

1
Department of Surgery, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden. linnea.huss@med.lu.se.
2
Department of Surgery, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden.
3
Department of Clinical Sciences, Malmö Clinical Research Centre, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden.
4
Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
5
Clinical Trial Unit, Skåne University Hospital, SE-221 85, Lund, Sweden.
6
Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
7
Centre for Primary Health Care Research, Lund University, SE-205 02, Malmö, Sweden.

Abstract

BACKGROUND:

It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) to be associated with vitamin D. The aim of this study was to investigate such vitamin D-SNP associations in relation to subsequent breast cancer risk. A first step included verification of these SNPs as determinants of vitamin D levels.

METHODS:

The Malmö Diet and Cancer Study included 17,035 women in a prospective cohort. Genotyping was performed and was successful in 4058 nonrelated women from this cohort in which 865 were diagnosed with breast cancer. Levels of vitamin D (25-hydroxyvitamin D) were available for 700 of the breast cancer cases and 643 of unaffected control subjects. SNPs previously associated with vitamin D in GWASs were identified. Logistic regression analyses yielding ORs with 95% CIs were performed to investigate selected SNPs in relation to low levels of vitamin D (below median) as well as to the risk of breast cancer.

RESULTS:

The majority of SNPs previously associated with levels of vitamin D showed a statistically significant association with circulating vitamin D levels. Heterozygotes of one SNP (rs12239582) were found to have a statistically significant association with a low risk of breast cancer (OR 0.82, 95% CI 0.68-0.99), and minor homozygotes of the same SNP were found to have a tendency towards a low risk of being in the group with low vitamin D levels (OR 0.72, 95% CI 0.52-1.00). Results from stratified analyses showed diverse associations with breast cancer risk for a few of the tested SNPs, depending on whether vitamin D level was high or low.

CONCLUSIONS:

SNPs associated with vitamin D may also be associated with the risk of breast cancer. Even if such a risk is small, the allele frequency of the SNP variants is high, and therefore the population attributable risk could be substantial. It is also possible that vitamin D levels may interact with genomic traits with regard to breast cancer risk.

KEYWORDS:

Breast cancer; Polymorphism; SNP; Vitamin D

PMID:
29291743
PMCID:
PMC5748964
DOI:
10.1186/s13058-017-0925-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center