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Trends Biochem Sci. 2018 Mar;43(3):149-151. doi: 10.1016/j.tibs.2017.12.004. Epub 2017 Dec 28.

Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination.

Author information

1
School of Chemistry, University of Wollongong, Northfields Ave, Wollongong, Australia, 2522; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, Australia, 2522; These authors contributed equally to this work.
2
School of Chemistry, University of Wollongong, Northfields Ave, Wollongong, Australia, 2522; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, Australia, 2522. Electronic address: vanoijen@uow.edu.au.

Abstract

Cells use a suite of specialized enzymes to repair chromosomal double-strand breaks (DSBs). Two recent studies describe how single-molecule fluorescence imaging techniques are used in the direct visualization of some of the key molecular steps involved. De Tullio et al. and Kaniecki et al. watch individual Srs2 helicase molecules disrupt repair intermediates formed by RPA, Rad51, and Rad52 on DNA during homologous recombination.

PMID:
29290471
DOI:
10.1016/j.tibs.2017.12.004
[Indexed for MEDLINE]

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