Format

Send to

Choose Destination
Biol Blood Marrow Transplant. 2018 Apr;24(4):700-707. doi: 10.1016/j.bbmt.2017.12.798. Epub 2017 Dec 28.

Tandem Autologous Hematopoietic Cell Transplantation for Patients with Primary Progressive or Recurrent Hodgkin Lymphoma: A SWOG and Blood and Marrow Transplant Clinical Trials Network Phase II Trial (SWOG S0410/BMT CTN 0703).

Author information

1
Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California. Electronic address: esmith@coh.org.
2
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
3
James P. Wilmot Cancer Center, University of Rochester, Rochester, New York.
4
Department of Pathology, University of Arizona, Tucson, Arizona.
5
Molecular Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
6
Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, California.
7
Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California.
8
Fred Hutchinson Cancer Research Center, University of Washington and Pacific Cancer Research Consortium NCORP, Seattle, Washington.
9
Hematology/Oncology, University of Chicago, Chicago, Illinois.
10
Fox Chase Cancer Center, Temple University, Philadelphia, Pennsylvania.
11
Hematology/Oncology, Loyola University Medical Center, Maywood, Illinois.

Abstract

Based on promising pilot data a phase II tandem autologous hematopoietic stem cell transplant (AHSCT) trial for relapsed/refractory Hodgkin lymphoma (HL) was performed in the US intergroup setting to determine if long-term progression-free survival (PFS) could be improved. Patients were enrolled after salvage therapy and stem cell collection. Sensitivity to salvage was defined by 1999 Standardized Response Criteria and did not include fluorodeoxyglucose-positron emission tomography. Cycle 1 consisted of melphalan 150 mg/m2 with half of the stem cells. For stable disease or better, patients received cycle 2 consisting of single doses of etoposide 60 mg/kg and cyclophosphamide 100 mg/kg and either total body radiation 12 Gy in 8 fractions over 4 days or BCNU 150 mg/m2/day for 3 days with the remaining stem cells. Of 98 enrolled patients, 89 were eligible and treated: 82 completed both cycles of AHSCT, 47 (53%) had primary refractory HL, and 72 (81%) were resistant to salvage therapy. There were no treatment-related deaths in the first year after AHSCT. With a median follow-up of 6.2 years (range, 2 to 7.7) for eligible patients who remained alive, the 2-year and 5-year PFS were 63% (95% CI, 52% to 72%) and 55% (95% CI, 44% to 64%) respectively; the 2-year and 5-year overall survival were 91% (95% CI, 83% to 95%) and 84% (95% CI, 74% to 90%), respectively. Univariate Cox regression analysis showed Zubrod performance status and lactate dehydrogenase levels > 1 times upper limit of normal at the time of enrollment were significantly associated with PFS. The observed 5-year PFS of 55% suggests the tandem approach appears to be effective in treating HL patients demonstrated to have poor prognosis in prior single AHSCT trials. This trial was registered at www.clinicaltrials.gov as NCT00233987.

KEYWORDS:

Autologous stem cell transplant; Hodgkin lymphoma; Tandem transplant

PMID:
29289757
PMCID:
PMC5965270
[Available on 2019-04-01]
DOI:
10.1016/j.bbmt.2017.12.798

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center