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J Dermatol Sci. 2018 Apr;90(1):3-12. doi: 10.1016/j.jdermsci.2017.12.009. Epub 2017 Dec 26.

Skin wound healing in humans and mice: Challenges in translational research.

Author information

1
Department of Biology, Embryology and Genetics, Federal University of Santa Catarina, Brazil. Electronic address: helena.zomer@posgrad.ufsc.br.
2
Department of Biology, Embryology and Genetics, Federal University of Santa Catarina, Brazil; National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil. Electronic address: andrea.trentin@ufsc.br.

Abstract

Despite the great progress in translational research concerning skin wound healing in the last few decades, no animal model fully predicts all clinical outcomes. The mouse is the most commonly used model, as it is easy to maintain and standardize, and is economically accessible. However, differences between murine and human skin repair, such as the contraction promoted by panniculus carnosus and the role of specific niches of skin stem cells, make it difficult to bridge the gap between preclinical and clinical studies. Therefore, this review highlights the particularities of each species concerning skin morphophysiology, immunology, and genetics, which is essential to properly interpret findings and translate them to medicine.

KEYWORDS:

Comparison; Cutaneous repair; Men; Mouse; Mus musculus

PMID:
29289417
DOI:
10.1016/j.jdermsci.2017.12.009
[Indexed for MEDLINE]

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