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Chimia (Aarau). 2017 Dec 1;71(12):823-835. doi: 10.2533/chimia.2017.823.

The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-α-Santalol and (-)-(Z)-β-Santalol.

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Firmenich SA, Corporate R&D Division, P.O. Box 239, CH-1211 Geneva 8;, Email:


The synthetic challenges associated with the selective synthesis of α-Santalene (1), (Z)-α-Santalol (2), β-Santalene (3), and most importantly (Z)-β-Santalol (4) have interested the world's synthetic chemists for decades. These molecules, lovely examples of nature's exquisite creations, have been isolated from East Indian Sandalwood Oil (Santalum album L.) and have stimulated chemists to develop new and efficient methodologies to synthesize them. The synthesis and evolution of various approaches to the [2.2.1]bicycloheptane ring system present in β-Santalene (3) and the even more challenging selective synthesis of the (Z)-allylic alcohol sidechain present in both (Z)-α-Santalol (2) and ((Z)-β-Santalol (4) will be covered in this review.


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