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Metabolism. 2018 May;82:58-64. doi: 10.1016/j.metabol.2017.12.006. Epub 2017 Dec 28.

A prospective study of the impact of diabetes mellitus on restrictive and obstructive lung function impairment: The Saku study.

Author information

1
Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. Electronic address: 25b16803@sahs.med.osaka-u.ac.jp.
2
Department of Fundamental Nursing, Graduate School of Nursing, Osaka Prefecture University, Habikino, Japan.
3
Department of Hygiene and Public Health, Teikyo University, Itabashi-ku, Japan.
4
Saku Central Hospital, Saku, Japan.
5
Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan.

Abstract

BACKGROUND:

To assess the impact of diabetes on restrictive and obstructive lung function impairment.

METHODS:

This 5-year prospective study included 7524 participants aged 40-69years without lung function impairment at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Diabetes was defined by fasting plasma glucose ≥7.0mmol/l (126mg/dl), HbA1c≥6.5% (48mmol/mol), or a history of diabetes, as determined by interviews conducted by the physicians. Restrictive and obstructive lung function impairment were defined as forced vital capacity (FVC) <80% predicted and forced expiratory volume in 1s (FEV1) to FVC ratio (FEV1/FVC) <0.70, respectively. Participants were screened until they developed restrictive or obstructive lung function impairment or until March 2014.

RESULTS:

During the follow-up period, 171 and 639 individuals developed restrictive and obstructive lung function impairment, respectively. Individuals with diabetes had a 1.6-fold higher risk of restrictive lung function impairment than those without diabetes after adjusting for sex, age, height, abdominal obesity, smoking status, exercise habits, systolic blood pressure, HDL-cholesterol, log-transformed high-sensitivity C-reactive protein, and baseline lung function [multivariable-adjusted HR and 95% CI; 1.57 (1.04-2.36)]. In contrast, individuals with diabetes did not have a significantly higher risk of obstructive lung function impairment [multivariable-adjusted HR and 95% CI; 0.93 (0.72-1.21)].

CONCLUSION:

Diabetes was associated with restrictive lung function impairment but not obstructive lung function impairment.

KEYWORDS:

Diabetes mellitus; Obstructive lung function impairment; Restrictive lung function impairment

PMID:
29288691
DOI:
10.1016/j.metabol.2017.12.006
[Indexed for MEDLINE]

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