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Metabolism. 2018 May;82:58-64. doi: 10.1016/j.metabol.2017.12.006. Epub 2017 Dec 28.

A prospective study of the impact of diabetes mellitus on restrictive and obstructive lung function impairment: The Saku study.

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Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. Electronic address:
Department of Fundamental Nursing, Graduate School of Nursing, Osaka Prefecture University, Habikino, Japan.
Department of Hygiene and Public Health, Teikyo University, Itabashi-ku, Japan.
Saku Central Hospital, Saku, Japan.
Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan.



To assess the impact of diabetes on restrictive and obstructive lung function impairment.


This 5-year prospective study included 7524 participants aged 40-69years without lung function impairment at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Diabetes was defined by fasting plasma glucose ≥7.0mmol/l (126mg/dl), HbA1c≥6.5% (48mmol/mol), or a history of diabetes, as determined by interviews conducted by the physicians. Restrictive and obstructive lung function impairment were defined as forced vital capacity (FVC) <80% predicted and forced expiratory volume in 1s (FEV1) to FVC ratio (FEV1/FVC) <0.70, respectively. Participants were screened until they developed restrictive or obstructive lung function impairment or until March 2014.


During the follow-up period, 171 and 639 individuals developed restrictive and obstructive lung function impairment, respectively. Individuals with diabetes had a 1.6-fold higher risk of restrictive lung function impairment than those without diabetes after adjusting for sex, age, height, abdominal obesity, smoking status, exercise habits, systolic blood pressure, HDL-cholesterol, log-transformed high-sensitivity C-reactive protein, and baseline lung function [multivariable-adjusted HR and 95% CI; 1.57 (1.04-2.36)]. In contrast, individuals with diabetes did not have a significantly higher risk of obstructive lung function impairment [multivariable-adjusted HR and 95% CI; 0.93 (0.72-1.21)].


Diabetes was associated with restrictive lung function impairment but not obstructive lung function impairment.


Diabetes mellitus; Obstructive lung function impairment; Restrictive lung function impairment

[Indexed for MEDLINE]

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