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Biotechnol Bioeng. 2018 May;115(5):1340-1354. doi: 10.1002/bit.26536. Epub 2018 Jan 29.

Gold nanorod-photosensitizer conjugates with glutathione-sensitive linkages for synergistic cancer photodynamic/photothermal therapy.

Author information

1
Graduate School of Energy Science and Technology, Chungnam National University, Daejeon, Korea.
2
Department of Physical Pharmacy, College of Pharmacy, Chungnam National University, Daejeon, Korea.
3
Department of Chemical Engineering Education, College of Education, Chungnam National University, Daejeon, Korea.

Abstract

Recently, photodynamic therapy (PDT) has been intensively investigated as a useful modality for the treatment of various cancers. In addition, near infrared (NIR) photothermal therapy (PTT) using gold nanocarriers has attracted particular interest as a hyperthermia strategy. In this study, gold nanorod (AuNR)-photosensitizer conjugates with glutathione-sensitive linkages were designed for PDT and PTT. Several kinds of AuNRs with different aspect ratios were synthesized and modified with FA-conjugated block copolymers (FA-PEG-P(Asp)-DHLA) and Chlorin e6 (Ce6) as a photosensitizer. The surface-modified AuNRs showed excellent stability and solubility in aqueous solution. In particular, FA-PEG-P(Asp)-DHLA-AuNR100-SS-Ce6 with a 3.84 aspect ratio exhibited strong photothermal effects, enhanced singlet oxygen generation, and marked phototoxicity. Based on these results, we suggest that AuNR-photosensitizer conjugates with glutathione-sensitive linkages have potential application in PDT/PTT for effective clinical treatment of various cancers.

KEYWORDS:

drug delivery; gold nanorod; photodynamic therapy; photothermal therapy; targeting

PMID:
29288576
DOI:
10.1002/bit.26536
[Indexed for MEDLINE]

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