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J Allergy Clin Immunol. 2018 Feb;141(2):491-498. doi: 10.1016/j.jaci.2017.12.979. Epub 2017 Dec 26.

Immune mechanisms of oral immunotherapy.

Author information

1
Department of Pediatrics, University of North Carolina, Chapel Hill, NC.
2
Department of Pediatrics, Massachusetts General Hospital, Boston, Mass.
3
Department of Immunology, Benaroya Research Institute, Seattle, Wash.
4
Department of Pediatrics, University of North Carolina, Chapel Hill, NC. Electronic address: bvickery@email.unc.edu.

Abstract

Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.

KEYWORDS:

B cells; Oral immunotherapy; T cells; antibodies; basophils; desensitization; immune mechanisms; mast cells; sustained unresponsiveness

PMID:
29288078
DOI:
10.1016/j.jaci.2017.12.979

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