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Gastroenterology. 2018 Mar;154(4):820-838. doi: 10.1053/j.gastro.2017.11.280. Epub 2017 Dec 26.

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

Author information

1
The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
2
Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, Scotland, United Kingdom.
3
The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: m.pajic@garvan.org.au.
4
The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: p.timpson@garvan.org.au.

Abstract

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.

KEYWORDS:

Diagnostic Tool; Invasion; Metastasis; Pancreatic Cancer; Patient-Derived Models; Stromal Remodeling

PMID:
29287624
DOI:
10.1053/j.gastro.2017.11.280
[Indexed for MEDLINE]

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