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Curr Opin Neurobiol. 2018 Feb;48:131-138. doi: 10.1016/j.conb.2017.12.005. Epub 2017 Dec 26.

Neural stem cells in neuropsychiatric disorders.

Author information

1
Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria.
2
Sapienza, University of Rome, Department of Biology and Biotechnology "Charles Darwin", Rome, Italy.
3
Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria. Electronic address: mailto:gnovarino@ist.ac.at.

Abstract

The precise control of neural stem cell (NSC) proliferation and differentiation is crucial for the development and function of the human brain. Here, we review the emerging links between the alteration of embryonic and adult neurogenesis and the etiology of neuropsychiatric disorders (NPDs) such as autism spectrum disorders (ASDs) and schizophrenia (SCZ), as well as the advances in stem cell-based modeling and the novel therapeutic targets derived from these studies.

PMID:
29287246
DOI:
10.1016/j.conb.2017.12.005
[Indexed for MEDLINE]

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