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J Pharm Bioallied Sci. 2017 Nov;9(Suppl 1):S237-S240. doi: 10.4103/jpbs.JPBS_141_17.

Assessment of Total Antioxidant Capacity and Antimicrobial Activity of Glycyrrhiza glabra in Saliva of HIV-Infected Patients.

Author information

1
Department of Public Health Dentistry, Mar Baselios Dental College, Kothamangalam, Kerala, India.
2
Department of Pedodontics, Annoor Dental College and Hospital, Muvattupuzha, Kerala, India.
3
Department of Prosthodontics, Mar Baselios Dental College, Kothamangalam, Kerala, India.
4
Department of Oral and Maxillofacial Surgery, Annoor Dental College and Hospital, Muvattupuzha, Kerala, India.
5
Department of Oral and Maxillofacial Surgery, Malabar Dental College and Research Center, Edappal, Kerala, India.
6
Department of Orthodontics, Annoor Dental College and Hospital, Muvattupuzha, Kerala, India.
7
Department of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Pondicherry, India.
8
Department of Public Health, Western University, Ontario, Canada.

Abstract

Objectives:

The objectives of this study were to evaluate the antimicrobial activity and total antioxidant capacity (TAC) of licorice in Saliva of HIV/AIDS patients.

Materials and Methods:

Saliva specimens were collected from 20 people living with HIV infection, with CD4 count <500 cells/mm3 from people infected with HIV/AIDS in Mangalore city, India. A combination of amoxicillin-clavulanic acid and nystatin was taken as the positive control and normal saline as negative control. Results were compared using one-way analysis of variance followed by Tukey's post hoc analysis in SPSS 19.

Results:

The TAC was evaluated spectrophotometrically at 695nm using the phosphomolybdenum method. Glycyrrhiza glabra showed a statistically significant reduction (P < 0.05) in total Candida count. The TAC of G. glabra was found to be 4.467 mM/L.

Conclusions:

G. glabra extracts showed good anticandidal activity and also high antioxidant property which reduces the oxidative stress of HIV-infected people.

KEYWORDS:

Antibacterial activity; Glycyrrhiza glabra; HIV/AIDS; total antioxidant capacity

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