Format

Send to

Choose Destination
Genes Dev. 2017 Nov 15;31(22):2204-2221. doi: 10.1101/gad.307702.117.

Chromatin and nucleosome dynamics in DNA damage and repair.

Author information

1
Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
2
Faculty of Natural Sciences, University of Basel, CH-4056 Basel, Switzerland.

Abstract

Chromatin is organized into higher-order structures that form subcompartments in interphase nuclei. Different categories of specialized enzymes act on chromatin and regulate its compaction and biophysical characteristics in response to physiological conditions. We present an overview of the function of chromatin structure and its dynamic changes in response to genotoxic stress, focusing on both subnuclear organization and the physical mobility of DNA. We review the requirements and mechanisms that cause chromatin relocation, enhanced mobility, and chromatin unfolding as a consequence of genotoxic lesions. An intriguing link has been established recently between enhanced chromatin dynamics and histone loss.

KEYWORDS:

DNA damage; chromatin structure; histones; nuclear organization; nucleosome remodelers

PMID:
29284710
PMCID:
PMC5769766
DOI:
10.1101/gad.307702.117
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center