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J Vet Sci. 2018 May 31;19(3):472-476. doi: 10.4142/jvs.2018.19.3.472.

Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected by Leishmania infantum.

Author information

1
Department of Veterinary Sciences, University of Pisa, 56122 Pisa, Italy.
2
ANUBI Companion Animal Hospital, 10024 Moncalieri, Italy.

Abstract

Three dogs were evaluated for severe hyperproteinemia and hyperglobulinemia secondary to Leishmania infantum. Double filtration plasmapheresis (DFPP) was performed in two dogs at days 1, 2, and 6 after presentation. The third dog received DFPP at days 1 and 3 after presentation and eleven hemodialysis treatments. Significant reduction in serum total protein (p < 0.0001), alpha-1 (p = 0.023), alpha-2 (p = 0.018), gamma globulins (p = 0.0105), and a significant increase in albumin/globulin ratio (p = 0.0018) were found. DFPP may be a promising therapeutic technique for rapid resolution of signs of hyperproteinemia in dogs affected by L. infantum.

KEYWORDS:

Leishmania infantum; dogs; double filtration plasmapheresis; hyperproteinemia

PMID:
29284208
PMCID:
PMC5974530
DOI:
10.4142/jvs.2018.19.3.472
[Indexed for MEDLINE]
Free PMC Article

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