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Ann Neurol. 2018 Jan;83(1):142-152. doi: 10.1002/ana.25129.

Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter.

Author information

1
Vascular Biology Center.
2
Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA.
3
Departments of Pediatrics.
4
Department of Pathology, University of Washington, Seattle, WA.
5
Preventive Medicine.
6
Group Health Research Institute, Seattle, WA.
7
Neurology, Oregon Health & Science University, Portland, OR.

Abstract

OBJECTIVE:

Microvascular brain injury (mVBI) is a common pathological correlate of vascular contributions to cognitive impairment and dementia (VCID) that leads to white matter (WM) injury (WMI). VCID appears to arise from chronic recurrent white matter ischemia that triggers oxidative stress and an increase in total oligodendrocyte lineage cells. We hypothesized that mVBI involves vasodilator dysfunction of white matter penetrating arterioles and aberrant oligodendrocyte progenitor cell (OPC) responses to WMI.

METHODS:

We analyzed cases of mVBI with low Alzheimer's disease neuropathological change in prefrontal cortex WM from rapid autopsies in a population-based cohort where VCID frequently occurs. Arteriolar vasodilator function was quantified by videomicroscopy. OPC maturation was quantified using lineage specific markers.

RESULTS:

Acetylcholine-mediated arteriolar dilation in mVBI was significantly reduced in WM penetrators relative to pial arterioles. Astrogliosis-defined WMI was positively associated with increased OPCs and was negatively associated with decreased mature oligodendrocytes.

INTERPRETATION:

Selectively impaired vasodilator function of WM penetrating arterioles in mVBI occurs in association with aberrant differentiation of OPCs in WMI, which supports that myelination disturbances in VCID are related to disrupted maturation of myelinating oligodendrocytes. Ann Neurol 2018;83:142-152.

PMID:
29283444
PMCID:
PMC5876126
DOI:
10.1002/ana.25129
[Indexed for MEDLINE]
Free PMC Article

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