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Lipids Health Dis. 2017 Dec 27;16(1):253. doi: 10.1186/s12944-017-0617-0.

Effects of 12-week supplementation of marine Omega-3 PUFA-based formulation Omega3Q10 in older adults with prehypertension and/or elevated blood cholesterol.

Author information

1
Department of Community Health and Behavior Medicine, School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, People's Republic of China.
2
Imaging Institute of Rehabilitation and Development of Brain Function, the Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, 637000, People's Republic of China. gxing99@yahoo.com.
3
Lotus Biotech.com LLC, John Hopkins University-MCC, 9601 Medical Center Drive, Rockville, MD, 20850, USA. gxing99@yahoo.com.
4
Department of Community Health and Behavior Medicine, School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, People's Republic of China. caiyong202028@163.com.
5
Department of Community Health and Family Medicine, Shanghai Jiao Tong University School of Public Health, Shanghai, 200025, People's Republic of China. caiyong202028@163.com.
6
Tang Qiao Community Health Service Center, Pudong New District, Shanghai, 200127, People's Republic of China.
7
Biochemistry Program, University of Maryland, Baltimore, MD, 21201, USA.
8
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
9
School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.

Abstract

BACKGROUNDS:

To study the effects of supplementation of a marine omega-3 poly-unsaturated fatty acids (n3-PUFA) formulation (Omega3Q10) in older adults with hypertension and/or hypercholesterolemia.

METHODS:

A total of 97 people were enrolled to receive 12-week supplementation of either Omega3Q10 (n = 48) or soybean oil (n = 49). Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and hypertension-related symptoms were determined before and after the supplementation.

RESULTS:

There were no baseline differences between the two groups. Omega3Q10 supplementation significantly reduced diastolic blood pressure (DBP) (from 81.6 ± 5.3 mmHg to 79.3 ± 5.2 mmHg, P < 0.05). Blood concentrations of TC and LDL-C decreased significantly and blood HDL-C level increased significantly after 12 weeks of Omega3Q10 (5.5 ± 0.7 vs. 5.3 ± 0.5, P < 0.05; 3.7 ± 0.8 vs. 3.3 ± 0.6, P < 0.05; 1.2 ± 0.6 vs. 1.3 ± 0.5, P < 0.05, respectively) and soybean oil supplementation (5.7 ± 0.8 vs. 5.6 ± 0.7, P < 0.05; 3.6 ± 0.7 vs. 3.4 ± 0.8, P < 0.05; 1.0 ± 0.8 vs. 1.2 ± 0.7, P < 0.05, respectively) but no group differences were found. A significantly greater proportion of the people in the Omega3Q10 group became free from headache and palpitations & chest tightness symptoms after the 12-week supplementation compared to that of the soybean oil group (95.5% vs. 71.4%, P < 0.01; 95.8 vs. 75.5%, P < 0.01, respectively).

CONCLUSION:

12-week supplementation of Fish oil-based PUFA appear to be more effective in improving DBP and hypertension-related symptoms than soybean oil in old adults with hypertension and hypercholesterolemia although both supplementation improved TC, LDL-C and HDL-C concentrations.

KEYWORDS:

Blood pressures, Dyslipidemia, Old adults; Fish oil-derived PUFA; Soybean oil

PMID:
29282085
PMCID:
PMC5745982
DOI:
10.1186/s12944-017-0617-0
[Indexed for MEDLINE]
Free PMC Article

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