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Curr Opin Cell Biol. 2018 Apr;51:89-96. doi: 10.1016/j.ceb.2017.12.007. Epub 2017 Dec 23.

Sugar sensing by ChREBP/Mondo-Mlx-new insight into downstream regulatory networks and integration of nutrient-derived signals.

Author information

1
Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
2
Faculty of Biological and Environmental Sciences, University of Helsinki, Finland; Institute of Biotechnology, University of Helsinki, Finland. Electronic address: ville.hietakangas@helsinki.fi.

Abstract

Animals regulate their physiology with respect to nutrient status, which requires nutrient sensing pathways. Simple carbohydrates, sugars, are sensed by the basic-helix-loop-helix leucine zipper transcription factors ChREBP/Mondo, together with their heterodimerization partner Mlx, which are well-established activators of sugar-induced lipogenesis. Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms and cross-connects with other nutrient sensing pathways. ChREBP/Mondo-Mlx controls several downstream transcription factors and hormones, which mediate not only readjustment of metabolic pathways, but also control feeding behavior, intestinal digestion, and circadian rhythm.

PMID:
29278834
DOI:
10.1016/j.ceb.2017.12.007
[Indexed for MEDLINE]

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