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Nanomedicine. 2018 Apr;14(3):781-788. doi: 10.1016/j.nano.2017.12.007. Epub 2017 Dec 24.

GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases.

Author information

1
Department of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil. Electronic address: peliky@icb.ufmg.br.
2
Department of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
3
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
4
Department of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil. Electronic address: frezard@icb.ufmg.br.

Abstract

There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neurotransmitter in the central nervous system, and dysfunction of GABAergic mechanisms is associated with different neurological conditions. Liposomes are lipid vesicles that are able to encapsulate chemical compounds and are used for chronic drug delivery. This short review reports our experience with the development of liposomes for encapsulation and chronic delivery of GABA to sites within the brain. Directions for future research regarding the efficacy and practical use of GABA-containing liposomes for extended periods of time as well as understanding and targeting neurological conditions are discussed.

KEYWORDS:

GABA; Liposomes; Nervous system; Neurological diseases; Neuroscience

PMID:
29278747
PMCID:
PMC6415746
DOI:
10.1016/j.nano.2017.12.007
[Indexed for MEDLINE]
Free PMC Article

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