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Curr Med Chem. 2017 Dec 25. doi: 10.2174/0929867325666171226103237. [Epub ahead of print]

Neuroprotective effects of flavonoid compounds on neuronal death associated to Alzheimer`s disease.

Author information

1
Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, E-07122 Palma de Mallorca, Balearic Islands. Spain.
2
Experimental Laboratory, Research Unit, Son LlĂ tzer Hospital, IUNICS, Ctra. Manacor km 4, E-07198, Palma de Mallorca, Balearic Islands. Spain.

Abstract

Alzheimer's disease is an increasing neurodegenerative pathology related to age in many societies. Some aspects of the disease are related to the loss of neuronal cells derived by the formation of extracellular neuritic plaques and the appearance of intracellular neurofibrillary tangles, altogether generate a inflammatory and oxidative status. The accumulation of amyloids in cells induces the activation of the apoptotic cascade which implies capases activation. Alzheimer's disease is treated with acetylcholine esterase inhibitors, although their effects are still far away to reduce or eliminate the problems associated with the pathology. The lack of effective treatment has led to the search for new therapeutic alternatives based on natural products. Flavonoids comprise a group of phenolic compounds that have gained great interest since they present great diversity of biological activities. In the present work, we review the potential uses of flavonoids and the proposed mechanisms of action as a new therapeutic strategy in neurological cell death associated with Alzheimer's disease.

KEYWORDS:

antioxidant; apoptosis; cytotoxicity; mitochondria; neurodegenerative; polyphenols

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