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Am J Geriatr Psychiatry. 2018 Apr;26(4):438-448. doi: 10.1016/j.jagp.2017.11.006. Epub 2017 Nov 22.

Baseline Mobility is Not Associated with Decline in Cognitive Function in Healthy Community-Dwelling Older Adults: Findings From The Irish Longitudinal Study on Ageing (TILDA).

Author information

1
From The Irish Longitudinal Study on Ageing, Trinity College, Dublin, Ireland. Electronic address: odonogh@tcd.ie.
2
Centre for Public Health, Queens University, Belfast, UK.
3
From The Irish Longitudinal Study on Ageing, Trinity College, Dublin, Ireland.

Abstract

OBJECTIVES:

Few studies examine the relationship between Timed Up-and-Go (TUG), a commonly used clinical test, and cognitive decline. This study examines whether TUG, usual gait speed (UGS), and dual-task gait speed (DTGS) predict decline in global cognition, executive function, processing speed, memory, and attention with follow-up of up to 5.9 years.

DESIGN:

Longitudinal study.

SETTING:

The Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort study.

PARTICIPANTS:

Community-dwelling adults aged ≥65 years, with Mini-Mental State Examination (MMSE) score ≥18 and no known history of memory impairment, dementia, Alzheimer's disease or Parkinson's disease were included (N = 2,250).

MEASUREMENTS:

Participants completed mobility tasks during the baseline health assessment and cognitive tasks during interviews conducted at 2 year intervals (waves 1, 2, and 3) and health assessments (waves 1 and 3). Linear and Poisson mixed effects regression models were used to examine longitudinal associations between mobility and each cognitive test, adjusting for sociodemographics and physical and mental health.

RESULTS:

There was little evidence of an association between TUG, UGS, or DTGS with decline in cognitive function after adjusting for confounders.

CONCLUSIONS:

These mobility tasks are not sensitive predictors of cognitive decline in this high-functioning, community-dwelling sample; nonetheless, limited decline in cognitive function was observed during follow-up. Further work with longer follow-up and/or analysis of more specific and comprehensive measures associated with gait is required.

KEYWORDS:

Gait speed; cognitive impairment; dual task; timed up-and-go

PMID:
29275903
DOI:
10.1016/j.jagp.2017.11.006

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