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Schizophr Res. 2017 Dec 21. pii: S0920-9964(17)30729-6. doi: 10.1016/j.schres.2017.11.031. [Epub ahead of print]

The brief negative symptom scale (BNSS): Sensitivity to treatment effects.

Author information

1
University of Nevada, Reno School of Medicine, Reno, NV, USA. Electronic address: bkirkpatrick@unr.edu.
2
PPRS Research, Inc., Groton, MA, USA.
3
Department of Psychology, University of Georgia, Athens, GA, USA.
4
Department of Psychiatry, Weill Cornell School of Medicine, USA.
5
ProPhase LLC, New York City, New York, USA.
6
Minerva Neurosciences, Inc., Waltham, MA, USA.

Abstract

The Brief Negative Symptom Scale (BNSS) grew out of a recommendation by the NIMH-sponsored Consensus Development Conference on Negative Symptoms that a scale based on contemporary concepts be developed. We assessed sensitivity to change of the BNSS in a trial of MIN-101, which showed efficacy for negative symptoms (PANSS pentagonal model) at daily doses of 32 and 64mg/day. Using mixed-effects model for repeated measures, we examined change in BNSS total score and in the BNSS factors of anhedonia/avolition/asociality (AAA), and expressivity (EXP). Compared to placebo, the 64mg group (N=83) showed a significant decrease in BNSS total score (effect size d [ES] 0.56, p<0.01) and both factor scores (AAA ES=0.48, EXP ES=0.46, p<0.02 for both). Patients in the trial had minimal depression and positive symptom scores; covarying for disorganization, positive symptoms, or anxiety/depression did not cause a meaningful change in the significance of the BNSS total or factor scores in this group. The 32mg group (N=78) did not differ significantly from placebo (N=83) on BNSS total score (ES=0.33, p<0.09), AAA (ES=0.25, p<0.20) or EXP (ES=0.30, p<0.12) scores. These results demonstrate the BNSS is sensitive to change.

KEYWORDS:

Factor analysis; Negative symptoms; Psychometrics; Schizophrenia; Treatment

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