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In Vivo. 2018 Jan-Feb;32(1):33-40.

Effect of Benifuuki Tea on Cytochrome P450-mediated Metabolic Activity in Rats.

Author information

1
Department of Pharmacology, Showa University, School of Medicine, Tokyo, Japan.
2
Department of Pharmacology, Showa University, School of Medicine, Tokyo, Japan yukin@med.showa-u.ac.jp.
3
Faculty of Arts and Sciences at Fujiyoshida, Showa University, Fujiyoshida, Japan.
4
Showa University Clinical Research Institute for Clinical Pharmacology and Therapeutics, Tokyo, Japan.
5
Department of Medical Education, Showa University, School of Medicine, Tokyo, Japan.

Abstract

BACKGROUND/AIM:

Benifuuki tea has recently been used as an alternative therapy for pollinosis, and it may be consumed with pharmaceutical drugs. This study aimed to examine cytochrome P450 (CYP)-mediated food-drug interactions with Benifuuki tea in rats.

MATERIALS AND METHODS:

The inhibitory effects of Benifuuki tea and (-)-epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) on CYP activities were evaluated in vitro. Midazolam pharmacokinetics was investigated after two treatments with Benifuuki tea. In an ex vivo study, CYP activities were determined after 1-week-treatment with the tea.

RESULTS:

Benifuuki tea and EGCG3"Me inhibited CYP2D and CYP3A activities in a concentration-dependent manner in vitro. However, MDZ metabolism did not change by Benifuuki treatment in vivo and ex vivo. In contrast, CYP2D activity was decreased ex vivo.

CONCLUSION:

Normal intake of Benifuuki tea is not likely to cause food-drug interactions by CYP3A inhibition or induction. In contrast, Benifuuki tea consumption may lead to food-drug interactions through the inhibition of CYP2D.

KEYWORDS:

Benifuuki tea; CYP2D; CYP3A; Cytochrome P450; food-drug interactions; pharmacokinetics

PMID:
29275296
PMCID:
PMC5892631
DOI:
10.21873/invivo.11201
[Indexed for MEDLINE]
Free PMC Article

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