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Cytokine. 2018 Feb;102:26-33. doi: 10.1016/j.cyto.2017.12.014. Epub 2017 Dec 21.

Interleukin-7 augments CD8+ T cells function and promotes viral clearance in chronic hepatitis C virus infection.

Author information

1
Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan Province 450003, China.
2
Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan Province 450003, China. Electronic address: shang_jiachina@163.com.

Abstract

Interleukin (IL)-7 is a potent proliferation, activation, and survival cytokine for CD8+ T cells to improve viral and tumor specific CD8+ T cell responses. However, the role of IL-7 in regulation of dysfunctional hepatitis C virus (HCV)-specific CD8+ T cells was not fully elucidated. Thus, a total of 53 patients with chronic hepatitis C and 24 healthy individuals were enrolled in the current study. Serum IL-7 and its receptor α chain CD127 expression was measured. The modulatory function of IL-7 to CD8+ T cells was investigated in both direct and indirect contact co-culture with HCVcc-infected Huh7.5 cells. Both serum IL-7 and CD127 expression on CD8+ T cells was significantly reduced in chronic HCV-infected patients, which was negatively correlated with HCV RNA. Stimulation of IL-7 promoted both cytotoxicity and cytokines (interferon-γ, tumor necrosis factor-α, and IL-2) production of CD8+ T cells from patients with chronic hepatitis C. Moreover, IL-7 increased proliferation of CD8+ T cells, while downregulated a critical repressor of cytokine signaling, suppressor of cytokine signaling 3 (SOCS3). The IL-7-mediated enhancement effects to CD8+ T cells were dependent on IL-6 production. The current data suggested that IL-7 induced both cytolytic and noncytolytic functions of CD8+ T cells probably via repression of SOCS3. IL-7 might be considered as one of the therapeutic candidates for treatment of chronic HCV infection.

KEYWORDS:

CD8(+) T cells; Hepatitis C virus; Interleukin-7; Viral persistence

PMID:
29275010
DOI:
10.1016/j.cyto.2017.12.014
[Indexed for MEDLINE]

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