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Matrix Biol. 2018 Nov;73:64-76. doi: 10.1016/j.matbio.2017.12.004. Epub 2017 Dec 21.

Matrix biomechanics and dynamics in pulmonary fibrosis.

Author information

1
Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States.
2
Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. Electronic address: Tschumperlin.daniel@mayo.edu.

Abstract

The composition and mechanical properties of the extracellular matrix are dramatically altered during the development and progression of pulmonary fibrosis. Recent evidence indicates that these changes in matrix composition and mechanics are not only end-results of fibrotic remodeling, but active participants in driving disease progression. These insights have stimulated interest in identifying the components and physical aspects of the matrix that contribute to cell activation and disease initiation and progression. This review summarizes current knowledge regarding the biomechanics and dynamics of the ECM in mouse models and human IPF, and discusses how matrix mechanical and compositional changes might be non-invasively assessed, therapeutically targeted, and biologically restored to resolve fibrosis.

PMID:
29274939
PMCID:
PMC6013326
[Available on 2019-11-01]
DOI:
10.1016/j.matbio.2017.12.004
[Indexed for MEDLINE]

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