Send to

Choose Destination
Cytokine. 2018 Feb;102:18-25. doi: 10.1016/j.cyto.2017.12.016. Epub 2017 Dec 21.

Low-to-moderate intensity aerobic exercise training modulates irritable bowel syndrome through antioxidative and inflammatory mechanisms in women: Results of a randomized controlled trial.

Author information

Department of Sports Medicine, Justus-Liebig-University, Giessen, Germany. Electronic address:
Department of Sport Injuries, Faculty of Physical Education and Sport Sciences, Allameh Tabataba'i University, Tehran, Iran. Electronic address:
Department of Sports Medicine, Justus-Liebig-University, Giessen, Germany. Electronic address:
Department of Nursing, Mount Saint Mary's University, Los Angeles, CA, United States. Electronic address:
Leibniz University, Hannover, Department of Sports Science, Hannover, Germany. Electronic address:
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address:
Department of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran. Electronic address:


Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exercise in sedentary IBS patients. A total of 109 female volunteers (aged 18-41 yrs) who fulfilled Rome III criteria for the diagnosis of IBS were screened and 60 were randomized to exercise (EX, n = 30) and non-exercise (NON-EX, n = 30) groups. Exercise intervention favorably attenuated inflammation as indicated by plasma cytokines (IL-1β, IL-6, IL-8, IL-10 and TNF-α), adenosine deaminase, oxidative stress (XO, MDA and NO) and enhanced antioxidants (SOD, CAT and GSH-Px) (P < .05), and these alterations correlate with promising improvements in IBS symptoms (P < .05). Taken together, low-to-moderate intensity exercise training program attenuates symptoms in IBS. Symptom improvement was associated with a reversal of the ratio of anti- to pro-inflammatory cytokines as well as facilitating blood redox homeostasis, suggesting an immune- and redox modulating function for exercise training.


Exercise intervention; Inflammation; Irritable bowel syndrome; Oxidative stress; Randomized controlled trial; Redox homeostasis


Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center