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Eur J Nutr. 2019 Feb;58(1):335-344. doi: 10.1007/s00394-017-1597-6. Epub 2017 Dec 22.

The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial.

Author information

1
Lincoln Institute for Health, University of Lincoln, Lincoln, UK.
2
Department of Infection, Immunity and Inflammation, College of Life Sciences, University of Leicester, Leicester, UK.
3
Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
4
Cambridge Centre for Health Services Research, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
5
Extremes Research Group, College of Health and Behavioural Sciences, Bangor University, Bangor, UK.
6
Endurance Research Group, School of Sport and Exercise Sciences, University of Kent at Medway, Chatham, ME4 4AG, UK. G.Davison@kent.ac.uk.

Abstract

BACKGROUND:

Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction, but there is a lack of research with clinically relevant in vivo measures.

AIM:

To investigate the effects of COL supplementation on in vivo immunity following prolonged exercise using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP).

METHODS:

In a double-blind design, 31 men were randomly assigned to COL (20 g/day) or placebo (PLA) for 58 days. Participants ran for 2 h at 60% maximal aerobic capacity on day 28 and received a primary DPCP exposure (sensitisation) 20 min after. On day 56, participants received a low-dose-series DPCP challenge to elicit recall of in vivo immune-specific memory (quantified by skinfold thickness 24 and 48 h later). Analysis of the dose-response curves allowed determination of the minimum dose required to elicit a positive response (i.e., sensitivity).

RESULTS:

There was no difference in summed skinfold thickness responses between COL and PLA at 24 h (p = 0.124) and 48 h (p = 0.405). However, sensitivity of in vivo immune responsiveness was greater with COL at 24 h (p < 0.001) and 48 h (p = 0.023) with doses ~ twofold greater required to elicit a positive response in PLA.

CONCLUSIONS:

COL blunts the prolonged exercise-induced decrease in clinically relevant in vivo immune responsiveness to a novel antigen, which may be a mechanism for reduced illness reports observed in the previous studies. These findings also suggest that CHS sensitivity is highly relevant to host defence.

KEYWORDS:

Contact hypersensitivity; Diphenylcyclopropenone; Host defence; Running; Whole integrated immune response

PMID:
29274034
PMCID:
PMC6425115
DOI:
10.1007/s00394-017-1597-6
[Indexed for MEDLINE]
Free PMC Article

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