Gram-negative bacteria remodel their surfaces to interact with the environment, particularly to protect pathogens from immune surveillance and host defenses. The enzyme AlmG is known to be involved in remodeling the Vibrio cholerae surface, but its specific role was not clear. A new study characterizes AlmG at the molecular level, showing it defies phylogenetic expectations to add amino acids to lipopolysaccharide (LPS). This LPS modification plays a pivotal role in V. cholerae resistance to antimicrobial peptides, weapons of the innate immune system against infections.
Keywords: Vibrio cholera; aminoacylation; antimicrobial peptide (AMP); lipid A; lipopolysaccharide (LPS); polymyxin B; synthetic biology.
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.