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Neurosci Lett. 2018 Feb 14;666:64-69. doi: 10.1016/j.neulet.2017.12.042. Epub 2017 Dec 19.

Long-term RF exposure on behavior and cerebral glucose metabolism in 5xFAD mice.

Author information

1
Division of Basic Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
2
Division of RI Research, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea.
3
Division of Basic Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea.
4
Radiation Non-Clinic Center, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea.
5
Department of EMF Research Team, Radio and Broadcasting Technology Laboratory, ETRI, Daejon, Republic of Korea.
6
Department of Radio Sciences and Engineering, College of Engineering, Chungnam National University, Daejon, Republic of Korea.
7
School of Electrical and Computer Engineering, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
8
Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea. Electronic address: yslee0425@ewha.ac.kr.
9
Division of Basic Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea. Electronic address: hjlee@kirams.re.kr.

Abstract

Given the increased public concern about the deleterious biological consequences of radiofrequency electromagnetic fields (RF-EMFs), the involvement of RF-EMFs in neurodegenerative diseases, especially Alzheimer's disease (AD), has received increased consideration. To investigate the effect of long-term RF-EMF exposure on AD progression, we exposed 5xFAD mice to 1950 MHz RF-EMF at a specific absorption rate of 5.0 W/kg for 2 h/day and 5 days/week for 8 months. Behavioral changes were assessed by an open field test and an object recognition memory task after RF exposure was terminated. In addition, cerebral glucose metabolism was analyzed in the brains of the 5xFAD mice using 18F-deoxyglucose positron emission tomography. The hyperactivity-like and anxiolytic behaviors of the 5xFAD mice in open field tests were rescued by RF exposure. Furthermore, long-term RF-EMF exposure improved the cognitive deficits of 5xFAD mice that were observed in the object recognition memory test. Consistent with the behavioral changes, glucose metabolism in the hippocampus and amygdala regions of the brains of 5xFAD mice following RF exposure was significantly increased compared to glucose metabolism in the brains of sham-exposed mice. These data suggest that long-term exposure to RF-EMF might exert beneficial effects on AD in 5xFAD mice.

KEYWORDS:

Alzheimer’s disease mice; Behavioral dysfunction; FDG-PET; RF-EMF

PMID:
29273398
DOI:
10.1016/j.neulet.2017.12.042
[Indexed for MEDLINE]

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