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Brain Res Bull. 2018 Mar;137:225-228. doi: 10.1016/j.brainresbull.2017.12.010. Epub 2017 Dec 19.

Brain activity-induced neuronal glucose uptake/glycolysis: Is the lactate shuttle not required?

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Department of Biochemistry, Yong Loo Lin School of Medicine, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore,. Electronic address:


The astrocyte-neuron lactate shuttle (ANLS) hypothesis posits that during neuronal activation, astrocytic glycolysis consumes glucose and generates lactate, with the latter then imported by neurons as a preferred fuel. The hypothesis has been controversial, with multiple theoretical postulates for and against, and with empirical evidence that were either supportive or otherwise. Recent findings using direct in vivo imaging of lactate and glucose uptake as well as associated metabolic changes in neurons have now placed important constraints on the hypothesis. Here, I review these recent findings and discuss their implications on neuronal energetics.


Astrocyte-neuron lactate shuttle (ANLS); Energy metabolism; Glycolysis; In vivo imaging; Lactate

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