Format

Send to

Choose Destination
Life Sci. 1989;44(11):711-5.

Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin.

Author information

1
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892.

Abstract

Resiniferatoxin, an extremely irritant diterpene present in several members of the genus Euphorbia, produced an 8 C decrease in the rectal temperature of mice with an effective dose in the range of 2-20 micrograms/kg. The structurally related natural product capsaicin produced a similar magnitude of fall in body temperature, albeit with 1000-fold lower potency. Tolerance to the hypothermic effects of both compounds readily developed and cross-tolerance between the compounds was observed. The extreme potency of resiniferatoxin should facilitate biochemical analysis of the mechanism of action of this class of compounds.

PMID:
2927241
DOI:
10.1016/0024-3205(89)90382-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center