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J Am Coll Nutr. 2018 Jan;37(1):71-79. doi: 10.1080/07315724.2017.1357509. Epub 2017 Dec 22.

Impact of Cranberry Juice Enriched with Omega-3 Fatty Acids Adjunct with Nonsurgical Periodontal Treatment on Metabolic Control and Periodontal Status in Type 2 Patients with Diabetes with Periodontal Disease.

Author information

1
a Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
2
b Student Research Committee, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
3
c Department of Nutrition , School of Para Medicine, Ahvaz Jundishapur University of Medical Science , Ahvaz , Iran.
4
d Department of Periodontology , School of Dentistry, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
5
e Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
6
f Biostatistics Division, Health Faculty , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
7
g Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.

Abstract

OBJECTIVES:

Cranberries, high in polyphenols, have been associated with a favorable glycemic response in patients with type 2 diabetes and also are beneficial for oral health. Because type 2 diabetes mellitus and periodontal disease have a physiological relationship, this study aimed to evaluate the hypothesis that cranberry juice enriched with omega-3 will improve glycemic and lipid profiles and periodontal status in patients with diabetes with periodontal disease.

MATERIALS AND METHODS:

In this randomized clinical trial, 41 patients with diabetes (age 35-67 years) with periodontal disease were recruited and randomly assigned to 4 groups: control (C; n = 12), receiving omega-3 (I1; n = 10, 1 g/ twice daily), cranberry juice (I2; n = 9, 200 ml, twice daily), and cranberry juice enriched with omega-3 (I3; n = 10, 200 ml, containing 1 g omega-3) twice daily for 8 weeks. Nonsurgical periodontal therapy was provided for all patients during the study. Fasting blood glucose and glycated hemoglobin, lipid profile, probing depth, anthropometric indices, and 3-day 24-hour dietary recalls were measured pre- and postintervention.

RESULTS:

Glycated hemoglobin was decreased significantly in I1 and I3 groups. Serum high-density lipoprotein cholesterol (HDL-C) levels increased significantly in the I3 group compared to baseline and compared to I1 and I2 groups. Probing depth was significantly reduced in all groups postintervention.

CONCLUSION:

Consumption of cranberry juice enriched with omega-3 can be beneficial as adjuvant therapy with nonsurgical periodontal therapy in decreasing glycated hemoglobin, increasing HDL-C, and improving periodontal status in patients with diabetes with periodontal disease.

KEYWORDS:

Type 2 diabetes mellitus; chronic periodontal disease; cranberry; glycosylated hemoglobin; lipid profile

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