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Int J Mol Sci. 2017 Dec 22;19(1). pii: E24. doi: 10.3390/ijms19010024.

Bio-Functional Design, Application and Trends in Metallic Biomaterials.

Author information

1
School of Mechanical Engineering and Automation, Xihua University, Chengdu 610039, China. yangke493@163.com.
2
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. changchunzhou@scu.edu.cn.
3
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. hsfan@scu.edu.cn.
4
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Fan_yujiang@scu.edu.cn.
5
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. jiangq@scu.edu.cn.
6
School of Manufacturing Science and Engineering, Sichuan University, Chengdu 610065, China. 2016223025082@stu.scu.edu.cn.
7
School of Manufacturing Science and Engineering, Sichuan University, Chengdu 610065, China. fanhy@scu.edu.cn.
8
Department of Applied Mechanics, Sichuan University, Chengdu 610065, China. yu_chen@scu.edu.cn.
9
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. zhangxd@scu.edu.cn.

Abstract

Introduction of metals as biomaterials has been known for a long time. In the early development, sufficient strength and suitable mechanical properties were the main considerations for metal implants. With the development of new generations of biomaterials, the concepts of bioactive and biodegradable materials were proposed. Biological function design is very import for metal implants in biomedical applications. Three crucial design criteria are summarized for developing metal implants: (1) mechanical properties that mimic the host tissues; (2) sufficient bioactivities to form bio-bonding between implants and surrounding tissues; and (3) a degradation rate that matches tissue regeneration and biodegradability. This article reviews the development of metal implants and their applications in biomedical engineering. Development trends and future perspectives of metallic biomaterials are also discussed.

KEYWORDS:

biodegradable metals; biological function design; biomechanical design; metal implants; porous structure

PMID:
29271916
PMCID:
PMC5795975
DOI:
10.3390/ijms19010024
[Indexed for MEDLINE]
Free PMC Article

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