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Intern Med. 2018 Apr 1;57(7):979-985. doi: 10.2169/internalmedicine.9242-17. Epub 2017 Dec 21.

A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges.

Author information

1
Department of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
2
Department of Pathology, University of Tsukuba, Japan.
3
Department of Surgery, University of Tsukuba, Japan.
4
Department of Molecular Laboratory Medicine, University of Tsukuba, Japan.

Abstract

We herein report a case of pheochromocytoma occurring in the course of Parkinson's disease. The coexistence of these two disease is extremely rare, with only four cases hitherto reported across the public databases. It is also noteworthy that biochemical tests, which are critical for the diagnosis of pheochromocytoma, are severely confounded by dopaminergic medications for Parkinson's disease, highlighting the importance of image-based modalities in this setting. We further attempted to gain insight into the potential molecular mechanisms, proposing that hypoxia-inducible factor signaling could make these two diseases mutually exclusive, while excessive reactive oxygen species could enable their coexistence.

KEYWORDS:

HIF-ROS; Parkinson's disease; dopaminergic medications; pheochromocytoma; rare coexistence

PMID:
29269645
PMCID:
PMC5919857
DOI:
10.2169/internalmedicine.9242-17
[Indexed for MEDLINE]
Free PMC Article

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