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Radiother Oncol. 2018 Mar;126(3):471-478. doi: 10.1016/j.radonc.2017.11.016. Epub 2017 Dec 18.

ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges.

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Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands.
Medical Software Solutions GmbH, Hagendorn, Switzerland.
CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Gray Laboratories, UK.
Department of Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg, Germany; National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.
Department of Radiation Oncology, University Hospital, Ludwig-Maximilians-University of Munich, Germany.
Centre for Cancer Research & Cell Biology, Queen's University Belfast, UK.
Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, Centre Léon Bérard, France.
Section for Biomedical Physics, Department of Radiation Oncology, University Hospital Tübingen, Germany.
Institute Biomedical Technology (IBiTech), Medical Imaging and Signal Processing (MEDISIP), Ghent University, Belgium.
Department of Radiation Oncology, University of Toronto, Department of Radiation Medicine, Princess Margaret Hospital, Canada.
Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Germany.
Division of Medical Radiation Physics, Department of Radiation Oncology and Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria.


Many radiotherapy research centers have recently installed novel research platforms enabling the investigation of the radiation response of tumors and normal tissues in small animal models, possibly in combination with other treatment modalities. Many more research institutes are expected to follow in the coming years. These novel platforms are capable of mimicking human radiotherapy more closely than older technology. To facilitate the optimal use of these novel integrated precision irradiators and various small animal imaging devices, and to maximize the impact of the associated research, the ESTRO committee on coordinating guidelines ACROP (Advisory Committee in Radiation Oncology Practice) has commissioned a report to review the state of the art of the technology used in this new field of research, and to issue recommendations. This report discusses the combination of precision irradiation systems, small animal imaging (CT, MRI, PET, SPECT, bioluminescence) systems, image registration, treatment planning, and data processing. It also provides guidelines for reporting on studies.


Image guided; Irradiation; Precision; Radiotherapy; Small animal

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