Format

Send to

Choose Destination
Clin Radiol. 2018 Apr;73(4):415.e1-415.e7. doi: 10.1016/j.crad.2017.11.007. Epub 2017 Dec 18.

Characterisation of meta-analytical functional connectivity in progressive supranuclear palsy.

Author information

1
Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA. Electronic address: frankfy21@gmail.com.
2
Department of Psychiatry, Yale School of Medicine, 333 Cedar St., New Haven, CT 06510, USA.
3
Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC 7800, San Antonio, TX 78229, USA.
4
Research Imaging Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229, USA.

Abstract

AIM:

To characterise the meta-analytical functional connectivity patterns in progressive supranuclear palsy (PSP) and compare them to idiopathic Parkinson's disease (IPD).

MATERIALS AND METHODS:

It was previously reported that PSP and IPD showed distinct regions of brain atrophy based on voxel-based morphometry (VBM) meta-analysis. Using these regions as seeds, healthy control data were referenced to create and statistically compare meta-analytical functional connectivity maps of PSP and IPD.

RESULTS:

Some overlap was noted between the two diseases, including within the thalamus, striatum, and prefrontal cortex; however, the PSP seeds demonstrated more extensive functional co-activity throughout the brain, particularly within the midbrain, precentral gyrus, parietal cortex, basal ganglia, and cerebellum.

CONCLUSION:

These findings may help guide future longitudinal studies in the development of new functional imaging biomarkers for diagnosis and assessing treatment response.

PMID:
29269038
DOI:
10.1016/j.crad.2017.11.007

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center