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Gynecol Endocrinol. 2018 Jul;34(7):601-604. doi: 10.1080/09513590.2017.1419173. Epub 2017 Dec 21.

Serum leptin level across different phases of menstrual cycle in normal weight and overweight/obese females.

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a Department of Physiology , College of Medicine, Imam Abdulrahman Bin Faisal University , Dammam , Saudi Arabia.


We compared serum leptin levels during various phases of menstrual cycle and its correlation with serum estradiol between normal weight and overweight/obese young females. Fifty-six young females with normal menstrual cycle were grouped into 26 normal weight and 30 overweight/obese subjects. Serum leptin and estradiol levels were measured during early follicular, pre-ovulatory and luteal phases of menstrual cycle in both groups using ELISA technique. Serum leptin levels were significantly different across different phases of menstrual cycle with a steady increment from follicular phase (9.97 ± 5.48 ng/dl) through pre-ovulatory phase (11.58 ± 6.49 ng/dl) with their peaks in luteal phase (12.52 ± 6.39 ng/dl, p < .001). Same pattern of change during menstrual phases was observed when the normal weight and overweight/obese group were analyzed separately. Serum leptin levels were significantly higher in overweight/obese group compared to normal weight subjects. In any of the study groups, leptin levels were not found to be correlated with estradiol level during different phases of menstrual cycle.


BMI; Leptin; estradiol; menstrual cycle

[Indexed for MEDLINE]

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