Format

Send to

Choose Destination
J Infect Dis. 2017 Dec 16;216(suppl_10):S897-S905. doi: 10.1093/infdis/jix511.

Neurological Implications of Zika Virus Infection in Adults.

Author information

1
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
2
Department of Microbiology, Universidad del Valle School of Medicine, Cali, Colombia.

Abstract

The 2015-2016 epidemic of Zika virus (ZIKV) in the Americas and the Caribbean was associated with an unprecedented burden of neurological disease among adults. Clinically, Guillain-Barre syndrome (GBS) predominated among regions affected by the ZIKV epidemic, but the spectrum of neurological disease in the adults appears broader as cases of encephalopathy, encephalitis, meningitis, myelitis, and seizures have also been reported. A para-infectious temporal profile of ZIKV-associated GBS (ZIKV-GBS) has been described in clinical studies, which may suggest a direct viral neuropathic effect. However, ZIKV neuropathogenesis has not yet been fully understood. Mechanisms for ZIKV-GBS and other neurological syndromes have been hypothesized, such as adaptive viral genetic changes, immunological interactions with other circulating flaviviruses, and host and factors. This review summarizes the current evidence on ZIKV-associated neurological complications in the adults.

KEYWORDS:

Guillain-Barre syndrome; Zika virus; adult population; neurological disease

PMID:
29267923
PMCID:
PMC5853915
DOI:
10.1093/infdis/jix511
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center