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J Gen Fam Med. 2017 Jun 21;18(6):436-438. doi: 10.1002/jgf2.91. eCollection 2017 Dec.

Irreversible metronidazole encephalopathy in an elderly woman with primary biliary cholangitis.

Author information

1
Division of General Internal Medicine Department of Medicine Tokai University Oiso Hospital Isehara Kanagawa Japan.
2
Division of General Internal Medicine Department of Medicine Tokai University Hospital Isehara Kanagawa Japan.
3
Department of Neurology Tokai University Oiso Hospital Isehara Kanagawa Japan.
4
Division of General Internal Medicine Family Medicine Program Tokai University Hospital Isehara Kanagawa Japan.

Abstract

An 82-year-old woman with primary biliary cholangitis was diagnosed with an irreversible neurological disorder, caused by metronidazole (MNZ)-induced encephalopathy. Although the disorder is a reversible pathological condition, in rare cases, it can cause serious sequelae or could even be fatal. Therefore, medications should be administered carefully, particularly in patients who require long-term administration of large doses or those with liver dysfunction.

KEYWORDS:

encephalopathy; irreversibility; liver dysfunction; metronidazole

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