Send to

Choose Destination
J Gen Fam Med. 2017 May 2;18(5):288-290. doi: 10.1002/jgf2.77. eCollection 2017 Oct.

Silicosis, then microscopic polyangiitis-antineutrophil cytoplasmic antibodies-associated vasculitis may be work-related disease in patients with silicosis.

Author information

Department of Internal Medicine Ako Central Hospital Hyogo Japan.
Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
Department of Cardiovascular Medicine Ako Central Hospital Hyogo Japan.


A 74-year-old man with silicosis was admitted to the hospital because of prolonged fever. After referral to internal medicine for persistent fever and renal dysfunction, workup revealed antineutrophil cytoplasmic antibodies (ANCA) positivity. He was diagnosed with microscopic polyangiitis (MPA). After treatment with immunosuppressive therapy, his condition improved. Herein, we discuss silica exposure and the risk of ANCA-associated vasculitis (AAV), particularly in terms of work-related diseases. Silica exposure is a notorious risk factor for developing AAV, which is potentially lethal when not identified. When we see a silicosis patient with new-onset prolonged fever and generalized fatigue, AAV should be taken into consideration. This case report provides beneficial information to reliably assess patients at high risk of developing AAV in primary care settings.


antineutrophil cytoplasmic antibodies; microscopic polyangiitis; silicosis; work‐related disease

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center