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J Agric Food Chem. 2018 Jan 10;66(1):99-107. doi: 10.1021/acs.jafc.7b03965. Epub 2017 Dec 20.

Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model.

Author information

1
BK21PLUS Glocal Education Program of Nutraceuticals Development, Konkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
2
Department of Applied Life Science, College of Biomedical and Health Science, Konkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
3
Institute of Biomedical and Health Science, Kunkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
4
Ahn-Gook Health., LTD. , Seoul 07445, Republic of Korea.
5
Research Institute of Inflammatory Diseases, Kunkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
6
Department of Life Science, College of Biomedical and Health Science, Konkuk University , 268 Chungwondaero, Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.

Abstract

The present study aimed to evaluate the preventive effects of highbush blueberry (Vaccinium corymbosum L.) vinegar (BV) on cognitive functions in a scopolamine (Sco)-induced amnesia model in mice. In this study, Sco (1 mg/kg, intraperitoneal injection) was used to induce amnesia. ICR mice were orally administered donepezil (5 mg/kg), blueberry extract (120 mg/kg), and BV (120 mg/kg) for 7 days. After inducing cognitive impairment by Sco, a behavioral assessment using behavior tests (i.e., Y-maze and passive avoidance tests) was performed. The BV group showed significantly restored cognitive function in the behavioral tests. BV facilitated cholinergic activity by inhibiting acetylcholinesterase activity, and enhanced antioxidant enzyme activity. Furthermore, BV was found to be rehabilitated in the cornu ammonis 1 neurons of hippocampus. In our study, we demonstrated that the memory protection conferred by BV was linked to activation of brain-derived neurotrophic factor (BDNF)/cAMP response element binding protein (CREB)/serine-threonine kinase (AKT) signaling.

KEYWORDS:

AChE activity; BDNF/CREB/AKT pathway; amnesia; behavior tests; blueberry vinegar; scopolamine

PMID:
29260547
DOI:
10.1021/acs.jafc.7b03965
[Indexed for MEDLINE]

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