Leydig cell tumor of the testis, presenting with azoospermia

Hatsuki Hibi; Kyoko Yamashita; Makoto Sumitomo; Yoshimasa Asada

doi:10.1002/rmb2.12046

Leydig cell tumor of the testis, presenting with azoospermia

Reprod Med Biol. 2017 Jul 20;16(4):392-395. doi: 10.1002/rmb2.12046. eCollection 2017 Oct.

Authors

Hatsuki Hibi¹, Kyoko Yamashita², Makoto Sumitomo³, Yoshimasa Asada⁴

Affiliations

¹ Department of Urology Kyoritsu General Hospital Nagoya Japan.
² Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan.
³ Department of Urology Aichi Medical University School of Medicine Nagakute Japan.
⁴ Asada Ladies Clinic Nagoya Japan.

Abstract

Case: A case of Leydig cell tumor, associated with azoospermia, is presented.

Outcome: The levels of sex hormones obviously were decreased, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), with elevated testosterone. Computed tomography revealed no adrenal gland tumor, but a significant calcification in the right scrotal content was observed. He received a right radical orchiectomy and then he was unable to ejaculate. An endocrine panel revealed significantly decreased levels of testosterone and the low LH level had remained. Hormone replacement therapy with combined LH and FSH successfully recovered and preserved spermatogenesis.

Conclusions: Although the patient's sexual function deteriorated after surgery, hormone replacement therapy was successful in establishing spermatogenesis.

Keywords: Leydig cell tumor; azoospermia; establishing spermatogenesis; hormone replacement therapy; infertility.

Publication types

Case Reports