Format

Send to

Choose Destination
Int J Mol Sci. 2017 Dec 18;18(12). pii: E2746. doi: 10.3390/ijms18122746.

Astragalus membranaceus-Polysaccharides Ameliorates Obesity, Hepatic Steatosis, Neuroinflammation and Cognition Impairment without Affecting Amyloid Deposition in Metabolically Stressed APPswe/PS1dE9 Mice.

Author information

1
Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan. jeremy0681@gmail.com.
2
Program in Molecular Medicine, School of Life Sciences, National Yang-Ming University, Taipei 11221, Taiwan. jeremy0681@gmail.com.
3
Institute of Neuroscience, Brain Research Center, School of Life Science, National Yang-Ming University, Taipei 11221, Taiwan.
4
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan. mklu@nricm.edu.tw.
5
Institute of Neuroscience, Brain Research Center, School of Life Science, National Yang-Ming University, Taipei 11221, Taiwan. hjtsay@ym.edu.tw.
6
Institute of Neuroscience, Brain Research Center, School of Life Science, National Yang-Ming University, Taipei 11221, Taiwan. whitebrake@hotmail.com.
7
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan. hk.liu@nricm.edu.tw.
8
Program in Clinical Drug Development of Chinese Herbal Medicine, Taipei Medical University, Taipei 11031, Taiwan. hk.liu@nricm.edu.tw.
9
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan. yshiao@nricm.edu.tw.
10
Institute of Biopharmaceutical Science, National Yang-Ming University, Taipei 11221, Taiwan. yshiao@nricm.edu.tw.

Abstract

Astragalus membranaceus is commonly used in traditional Chinese medicine for strengthening the host defense system. Astragalus membranaceus-polysaccharides is an effective component with various important bioactivities, such as immunomodulation, antioxidant, anti-diabetes, anti-inflammation and neuroprotection. In the present study, we determine the effects of Astragalus membranaceus-polysaccharides on metabolically stressed transgenic mice in order to develop this macromolecules for treatment of sporadic Alzheimer's disease, a neurodegenerative disease with metabolic risk factors. Transgenic mice, at 10 weeks old prior to the appearance of senile plaques, were treated in combination of administrating high-fat diet and injecting low-dose streptozotocin to create the metabolically stressed mice model. Astragalus membranaceus-polysaccharides was administrated starting at 14 weeks for 7 weeks. We found that Astragalus membranaceus-polysaccharides reduced metabolic stress-induced increase of body weight, insulin and insulin and leptin level, insulin resistance, and hepatic triglyceride. Astragalus membranaceus-polysaccharides also ameliorated metabolic stress-exacerbated oral glucose intolerance, although the fasting blood glucose was only temporally reduced. In brain, metabolic stress-elicited astrogliosis and microglia activation in the vicinity of plaques was also diminished by Astragalus membranaceus-polysaccharides administration. The plaque deposition, however, was not significantly affected by Astragalus membranaceus-polysaccharides administration. These findings suggest that Astragalus membranaceus-polysaccharides may be used to ameliorate metabolic stress-induced diabesity and the subsequent neuroinflammation, which improved the behavior performance in metabolically stressed transgenic mice.

KEYWORDS:

Alzheimer’s disease; Astragalus-polysaccharides; amyloid plaque; cognitive dysfunction; glia; metabolic stresses

PMID:
29258283
PMCID:
PMC5751345
DOI:
10.3390/ijms18122746
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center