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Curr Biol. 2017 Dec 18;27(24):R1309-R1311. doi: 10.1016/j.cub.2017.10.055.

Meiosis: The Origins of Bias.

Author information

1
Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
2
Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: abdesai@ucsd.edu.

Abstract

Biased, or non-Mendelian, segregation is frequently observed but not well understood. Two recent studies on a specific type of biased segregation in mammalian meiosis suggest that it arises from centromeric satellite expansion and asymmetric modification of microtubules in the oocyte spindle.

PMID:
29257963
DOI:
10.1016/j.cub.2017.10.055
[Indexed for MEDLINE]
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