Send to

Choose Destination
GE Port J Gastroenterol. 2017 Nov;24(6):279-284. doi: 10.1159/000455180. Epub 2017 Sep 6.

Hodgkin's Lymphoma in Crohn's Disease Treated with Infliximab.

Author information

Gastroenterology and Hepatology Department, Lisbon, Portugal.
Pathologic Department, Lisbon, Portugal.
General Surgery Department, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.


in English, Portuguese


Lymphoproliferative disorders, particularly non-Hodgkin's and Hodgkin's lymphomas, are rare in patients with inflammatory bowel diseases. The use of thiopurines and infection by Epstein-Barr virus are well-known cofactors that can raise its prevalence. Other risk factors such as disease activity and biological treatment are the subject of discussion, without enough data in the literature to confirm a potential association.


We report a case of Hodgkin's lymphoma in a patient who had been treated with azathioprine and was on long-term monotherapy with infliximab.


We stress the importance of recognizing the possible occurrence of a lymphoproliferative disorder in association with anti-tumor necrosis factor-α therapy.


Crohn's disease; Hodgkin's disease, chemically induced; Infliximab; Lymphoproliferative disorders; Tumor necrosis factor-α

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
Loading ...
Support Center