Format

Send to

Choose Destination
GE Port J Gastroenterol. 2017 Nov;24(6):279-284. doi: 10.1159/000455180. Epub 2017 Sep 6.

Hodgkin's Lymphoma in Crohn's Disease Treated with Infliximab.

Author information

1
Gastroenterology and Hepatology Department, Lisbon, Portugal.
2
Pathologic Department, Lisbon, Portugal.
3
General Surgery Department, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Abstract

in English, Portuguese

Introduction:

Lymphoproliferative disorders, particularly non-Hodgkin's and Hodgkin's lymphomas, are rare in patients with inflammatory bowel diseases. The use of thiopurines and infection by Epstein-Barr virus are well-known cofactors that can raise its prevalence. Other risk factors such as disease activity and biological treatment are the subject of discussion, without enough data in the literature to confirm a potential association.

Methods:

We report a case of Hodgkin's lymphoma in a patient who had been treated with azathioprine and was on long-term monotherapy with infliximab.

Conclusions:

We stress the importance of recognizing the possible occurrence of a lymphoproliferative disorder in association with anti-tumor necrosis factor-α therapy.

KEYWORDS:

Crohn's disease; Hodgkin's disease, chemically induced; Infliximab; Lymphoproliferative disorders; Tumor necrosis factor-α

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
Loading ...
Support Center