Format

Send to

Choose Destination
J Pediatr. 2018 Apr;195:275-278. doi: 10.1016/j.jpeds.2017.10.046. Epub 2017 Dec 15.

First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring.

Author information

1
Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Children's Hospital, University of Helsinki, Helsinki, Finland.
2
Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA.
3
Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA.
4
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
5
Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA; Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA. Electronic address: jpriest@stanford.edu.

Abstract

In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.

KEYWORDS:

congenital heart disease; congenital malformation; diabetes; oral glucose tolerance test; plasma glucose

PMID:
29254757
PMCID:
PMC5869072
DOI:
10.1016/j.jpeds.2017.10.046
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center